6月11日 Prof. Luoding Zhu学术报告

发布时间:2018-06-04

报告题目：Modeling and simulation of blood flow past the distal anastomosis of arteriovenous graft

主讲人：Prof. Luoding Zhu (Indiana University-Purdue University Indianapolis)

报告时间：2018年6月11日（星期一）下午14:30pm - 16:00pm

报告地点：数据科学与bat365在线中国登录入口 A201

主持：邹青松 教授

摘要：Arteriovenous grafting (AVG) is a common device applied in hemodialysis for kidney failure patients. It is often failed because of the intimal hyperplasia formed around the AVG anastomosis. In order to help understand the mechanism of the formation of intimal hyperplasia, we investigate the flow patterns and force distributions near the distal anastomosis by modeling and simulation. The anastomosis structure (graft and vein) is modeled by elastic fibers. The surrounding tissue is modeled by elastic springs in viscous fluid. The blood is modeled by viscous incompressible fluid and the flow is numerically simulated by the lattice-Boltzmann method. The fluid-structure-interaction is treated by the immersed boundary method. We perform series of simulations using different Reynolds numbers and AVG configurations including attached angles and vein-graft diameter ratio. Both rigid and deformable cases are considered. Flow fields are visualized and compared. Wall shear stress, wall shear stress gradient, wall normal stress gradient, etc. on the vein/AVG walls are computed and analyzed. Significant differences between the rigid and the deformable cases are found.

个人介绍：Prof. Zhu, PhD in Applied Math (2001), Courant Institute of Mathematical Sciences, New York University, MS in Fluid Dynamics (1992), Beijing Institute of Applied Physics and Computational Mathematics， BS in Mechanics (1989), Zhejiang University, now is a professor in Indiana University-Purdue University Indianapolis. Prof. Zhu expertize in applied computational mathematics, fluid mechanics, and scientific computing. Prof. Zhu is interested in numerical methods for and computer simulations of fundamental mechanical and/or biological processes which involve incompressible viscous fluids and elastic deformable boundaries. Blood flows in human vessels is a typical example. There are two major components of his research program: development of numerical methods for fluid-flexible-structure-interaction problems including extension/improvement of the immersed boundary (IB) methods, and applications of these methods to problems in (life) sciences/(biomedical) engineering. Currently Prof. Zhu focus on modeling and simulation of blood flows and fluid flow around osteocytes.